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<p><font size="6" face="Verdana"><font size="4"><font size="5"><font size="7"><strong><font color="#ff0000">V</font><font color="#ff6600">a</font><font color="#000000"><font color="#99cc00">r</font></font><font color="#3366ff">i</font><font color= Welcome to openfree BiO network"#0000ff">o</font><font color="#000000"><font color="#333399">m</font>e</font></strong></font><font color="#000000"><font size="7">.net</font><font size="4"><font size="5"><strong>:</strong></font></font></font><font color="#999999"><font size="4" face="Arial"> difference among individuals and populations in one species. </font><br /></font></font></font></font><br /><font size="6"><font size="4"><font color="#339966"><font size="3"><font color="#339966"><strong><font color="#006600"><table style="width: 765px; height: 23px" border="1" cellspacing="1" summary="" cellpadding="1" width="765"> <brtbody> <tr> <td><font color="#666699" size="4" face= '''BiO network "Times New Roman">The variome.net is on-line information source for all an <em>[[openfree]]</em> web resource and encyclopedia of world wide [[SNP]] (Single Nucleotide Polymorphism) researchers.&nbsp;The variome.net aims to support the areas of biological researchinternational genome variance researches by collecting, technologyorganizing, traininganalyzing, and businessdisseminating variome information.''' &nbsp;&nbsp;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<font size="3">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; &lt;[[about the logo]]&gt;</font></font></td> </tr> </tbody></table><br /></font><br />[[What&nbsp;are Variome and Variomics?]]:&nbsp;<br />[[Are humans a single species?]]<br /></strong></font></font></font></font></font></p><p>&nbsp;</p><p>&nbsp;</p><p>&nbsp;<strong><font size="4">Current&nbsp;Research (<em>Please list your projects here</em>)<br /><br /></font></strong></p><ul> <li><font size="4"><font size="3"><strong>Applications</strong></font></font></li></ul><blockquote><p><font size="4">&nbsp;Service Opened!</font></p><ul> <li><font size="3"><font color="#000000"><strong>SNP@Web</strong></font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; :&nbsp;SNP&nbsp;database and tool catalogs&nbsp; http://variome.kobic.re.kr/SNPatWEB/</font></li> <li><font size="3"><strong>SNP@Domain</strong> : A</font><span style="font-family: Tahoma; font-size: 14pt" lang="EN-US"><font size="3" face="Arial"> web resource of Single Nucleotide Polymorphisms (SNPs) within protein&nbsp;domain structures and sequences http://variome.kobic.re.kr/SnpNavigator/</font></span></li> <li><font color="#000000"><strong><font size="3">SNP@Ethnos</font></strong></font>&nbsp;&nbsp;: &nbsp;<font size="3">A database of&nbsp;Ethnically Variant SNPs</font>&nbsp;<font size="3">http://variome.kobic.re.kr/SNPatETHNIC/</font></li> <li><font size="3"><strong>SNP@Promoter</strong> <font color="#ff0000">(NEW!)</font>: A web resource of Single Nucleotide Polymorphisms (SNPs) within promoter. http://variome.kobic.re.kr/SNPatPromoter</font></li> <li><font size="3"><font color="#000000"><strong>SNP2NMD</strong></font><font color="#ff0000"><font color="#000000">&nbsp;</font>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </font>:&nbsp; A database of human SNPs resulting&nbsp;NMD PTC.<font size="2">&nbsp; </font><font size="3">http://variome.kobic.re.kr/SNP2NMD</font></font></li> <li><font size="3"><font size="3"><strong>SNP2SPLICE&nbsp;</strong>(Updating!)</font>: A database of Single Nucleotide Polymorphisms&nbsp;within splicing sites.</font></li> <li><font size="3"><strong>FESD</strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; : A web-based integrated database for selecting sets of SNPs in putative functional elements in human gene http://variome.kobic.re.kr/FESD</font></li> <li><font size="3"><strong>Alternatome</strong><font color= "#ff0000">&nbsp;(Coming soon!)&nbsp;</font>:&nbsp; A database of alternative splicing&nbsp;with splicing array&nbsp;to understand gene regulation. </font><br/> &nbsp;</li></ul><p><font size="4">Under development!</font></p><ul> <li><font size="3"><font color="#000000"><strong>MitoVariome</strong>: A database&nbsp;for variation on mitochondria</font></font></li> <li><font size="3"><font color="#000000"><strong>ALU2NMD</strong></font><font color="#ff0000">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </font>:&nbsp; A database of human ALUs resulting NMD.</font></li> <li><font size="3">[[Disease2Gene2SNP]] project with [http://istech21.com/en/ istech] members</font></li> <li><font size="4"><font size="3">SNP@Structural Domain&nbsp;: A web resource of Single Nucleotide Polymorphisms (SNPs) within structural protien domains</font></font></li> <li><font size= '''Anyone is welcome to contribute to and use "3"><strong>[[Alternative Splicing&nbsp;Resource]]</strong> : A&nbsp;web resource for the content with maximumalternative splicing events</font></li></ul><p>&nbsp;</p></blockquote><ul> <li><font size="4"><font size="3"><strong>Research</strong></font></font></li></ul><blockquote><ul style="margin-right: 0px" dir="ltr"> <li><span><font color="#0000ff" size="3"><font color="#ff6600">[SUBMITTED]</font>&nbsp;freedom.'<br /> </font></span><span><font size="3">SAPs (Single Amino acid Polymorphisms) with High Levels of Population Differentiation are Enriched in Transmembrane Protein Domains<span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font face="Arial"><br/> </font> </font></font></span></font></span><font size="3"><span>[[Dataset]]</span></font>&nbsp;&nbsp; <font size="3"><br /> </font></li> <li><font size="4"><font size="3">&nbsp;anlaysis SNPs within structural domains&nbsp;</font></font>&nbsp;</li> <li><font size="4"><font size="3">&nbsp;variation of gene expression and seuqences</font></font>&nbsp;&nbsp;</li> <li><font size="4"><font size="3">&nbsp;analysis SNPs within human -&nbsp;chimpanzee ortholog genes</font></font></li></ul><p dir="ltr">&nbsp;</p></blockquote><p><strong><font size="4">Infra Resources<br /></font></strong><font size= Please visit our sites that are listed in "3"><br /><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; from </strong>([http://www.kobic.re.kr <strong>KOBIC</strong>]).<font size="2">&nbsp;</font><br /><br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; [[SNPpipe]]: a collection of automatic downloading and parsing modules&nbsp; [http://bioportal.kobic.re.kr/SNPPipe/ Website]<br /></font><br /><font size="4"><strong>Web Resources&nbsp;<br /><br />&nbsp;&nbsp;&nbsp;&nbsp; <font size="3">from </font></strong><font size="3">([http://biositewww.kobic.re.orgkr <strong>KOBIC</strong>]). </font><font size="2">&nbsp;<br /><br /></font></font></p><ul> <li><span><font size="3"><font color="#ff0000"><font color="#008080"><span><font size="3"><font color="#99cc00"><font color="#339966">[ACCEPTED] <font color="#000000">in <em>BMC Bioinformatics</em></font><br /> </font></font></font></span></font></font></font></span><span><font size="3">SNP@Promoter&nbsp; <a href="http://variome.kobic.re.kr/SNPatPromoter/">http://variome.kobic.re.kr/SNPatPromoter/</a></font></span>&nbsp;<br /> <font size="3"><span>: Human SNP databases for transcription regulatory regions<font size="2">.</font></span></font><br /> <br/> &nbsp;</li> <li><span><font size="3"><font color="#ff0000"><font color="#008080"><span><font size="3"><font color="#99cc00"><font color= Some "#339966">[PUBLISHED] <br /> </font></font></font></span></font></font></font></span><span><font size="3">SNP2NMD&nbsp; http://variome.kobic.re.kr/SNP2NMD/</font></span>&nbsp;<br /> <font size="3"><span>: A database of our sites arehuman SNPs causing NMD (nonsense-mediated mRNA decay). </span></font><font size="2">http: //bioinformatics.oxfordjournals.org/cgi/content/abstract/23/3/397</font><br /> <br /> &nbsp;</li> <li><span><font size="3"><font color="#ff0000"><font color="#008080"><span><font size="3"><font color="#99cc00"><font color="#339966">[PUBLISHED] <br /> </font></font></font></span></font></font></font></span><span><font size="3">SNP@Ethnos&nbsp; http://variome.kobic.re.kr/SNPatETHNIC/</font></span>&nbsp;<br /> <font size="3"><span>: A database of Ethnically Variant SNPs.</span></font><br />[ <a href="http://biopedianar.oxfordjournals.org biopedia/cgi/content/full/35/suppl_1/D711"><font size="3">http://nar.oxfordjournals.org/cgi/content/full/35/suppl_1/D711</font></a></li></ul><p><br />&nbsp;</p><ul> <li><span><font size="3"><font color="#ff0000"><font color="#008080"><span><font size="3"><font color="#99cc00"><font color="#339966">[PUBLISHED][<br /> </font></font></font></span></font></font></font></span><span><font size="3">SNP@Domain&nbsp; <a href="http://variome.kobic.re.kr/SnpNavigator/">http://variome.kobic.re.kr/SnpNavigator/</a> or <a href="http://snpnavigator.net/">http://snpnavigator.net/</a></font></span><br /> <span><font size="3">: A web resource of Single Nucleotide Polymorphisms (SNPs) within protein domain structures and sequences.<br /> </font></span><a href="http://nar.oxfordjournals.org/cgi/content/full/34/suppl_2/W642"><font size="3">http://biopedianar.oxfordjournals.org /cgi/content/full/34/suppl_2/W642</font></a>&nbsp;&nbsp;&nbsp; <br /> <br /> &nbsp;</li> <li><span><font size="3"><font color="#99cc00"><font color="#339966">[PUBLISHED]<br /> </font></font></font></span><font size="3"><span>D2SNP&nbsp;&nbsp;<a href="http://combio.kribb.re.kr:8080/D2GSNP/index.faces">http://bioportal.kobic.re.kr:8080/D2GSNP/index.faces</a></span></font>&nbsp;<br /> <span><font size="3">: The free encyclopedia A web-based tools for the selection of a set of SNPs within candidate genes of biologyhuman diseases.<br /> </font></span><span><font size="3"><a href="http://www.kogo.or.kr/bulletin/UploadFile/rapidcom_1_200603.pdf">http://www.kogo.or.kr/bulletin/UploadFile/rapidcom_1_200603.pdf</a></font></span> <p><br /> &nbsp;</p> </li> <li><span><font size="4"><span><font size="3"><font color="#339966">[PUBLISHED]</font></font></span></font></span> <br /> <span><font size="4"><span><font size="3">FESD&nbsp;<font size="3"><a href="http://variome.kobic.re.kr/FESD">http://variome.kobic.re.kr/FESD</a></font></font></span></font></span><br /> <span><font size="4"><span><font size="3">:&nbsp;A web-based integrated database for selecting sets of SNPs in putative functional elements in human gene.</font></span></font></span><br /> <span><font size="4"><font size="3"><a href="http://biositesnar.oxfordjournals.org biosites/cgi/content/full/33/suppl_1/D518">http://nar.oxfordjournals.org]/cgi/content/full/33/suppl_1/D518</a></font>&nbsp;</font></span></li></ul><p><span><font size="4">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font></span><strong><font size="4"><br />Research results<br /></font></strong><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <font face="Arial"><strong>from </strong><font size="3">([http://biositeswww.org kobic.re.kr <strong>KOBIC</strong>]).</font><font size="2">&nbsp;</font></font><br /><br /></span></p><ul> <li><span><font size="3"><font color="#99cc00"><font color="#339966">[PUBLISHED]: The internet sites directory for biological science<br /> </font></font></font></span><font size="3"><span>Comparative study of the linkage disequilibrium of an ENCODE region, chromosome 7p15, in Korean, technologyJapanese, and businessHan Chinese samples.<br /> &nbsp;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=16376517">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=16376517</a></span></font></li></ul><p><font size="4"><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font size="4"><font face="Arial"><strong><br />Broadly External Links<br /><br /></strong><font size="3">[http://genomicspasnp.org Genomicsa PASNP site]: Pan Asia SNP project related site.<br /></font></font><font face="Arial"><font size="3">[http://biopedia.orgBiopedia],&nbsp;<br />[http://genomicswww.org [nsiphs.com/search.jsp siphs:a life sciences community],<br />[http://genomicswww.org meddb.info/index.php.en?cat=6&amp;subcat=114 Medicine and molecular biology DB]<br />[[dbGap]]: The free Oenomics portala Database of Genome Wide Association Studies<br />[http://www.sph.umich.edu/csg/qin/FESTA/ FESTA] tagSNP picker<br />[http://info.med.yale.edu/genetics/kkidd/programs.html Haplo, Haplot]<br />[http://omicsalfred.med.org Omicsyale.edu/ Allele Frequency Database at Yale.orgUSA]</font><br /><br /></font><strong><font face="Arial">[[Q &amp; A]]<br /><br />[[Opinions]]</font></strong></font></font></font></span></span>&nbsp;<br /></font><strong><font size="4"><br />Meetings and conferences<br /></font></strong>[http://omicswww.humanvariomeproject.org / International Meetings on Variome]<br />&nbsp;</p><p><strong><font size="4">SNP Basics</font></strong></p><ul> <li><a href="http://www.ncbi.nlm.nih.gov/About/primer/snps.html">SNPs: The Omics home page Variations on a Theme</a> - A basic introduction to SNPs from the National Center for everyoneBiotechnology Information (NCBI).</li> <li><a href="http://nci.nih.gov/cancertopics/understandingcancer/geneticvariation">Understanding SNPs and Cancer</a> - An online tutorial from the National Cancer Institute.</li>[ <li><a href="http://www.genetics.gsk.com/kids/medicine01.htm">Diseases and Medical Response</a> - An animated tutorial describing how DNA markers are used in medical applications. Part of the <a href="http://biocompanywww.genetics.net Biocompanygsk.com/kids/index_kids.htm">Kids Genetics</a> Web site from GlaxoSmithKline.net][</li> <li><a href="http://biocompanywww.net ]genomenewsnetwork.org/resources/whats_a_genome/Chp4_1.shtml">Genome Variations</a> - Questions and answers about genome variation from the Genome News Network.</li> <li><a href="http: //www.wellcome.ac.uk/en/1/biovensnpsnp.html">The Biocompany directory Cutting Edge: SNPs and information portal for entrepreneurship Their Medical Application</a> - From The Wellcome Trust.</li> <li><a href="http://www.wellcome.ac.uk/en/1/biovensnpblf.html">A Brief Guide to SNPs</a> - A set of questions and businessanswers from The Wellcome Trust. <br /> &nbsp;</li></ul><p><strong><font size="4">Variome Server</font> - </strong><a href="http://variome.kobic.re.kr"><strong>http://variome.kobic.re.kr</strong></a><br /><br /><br />&nbsp;</p><p><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font face="Arial"><font size="4"><strong>Members </strong><em>(everyone is welcome to participate in)</em></font></font></span></span></p><ul> <li><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font face="Arial">[[Areum Han]]</font></font></font></span></span><br /> &nbsp;</li> <li><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font face="Arial">[http://biocountrybio.net Biocountry.netcc/~neobio Sung Sam Gong]</font></font></font></span></span></li> <li><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font face="Arial">Yubok Cho</font></font></font></span></span></li> <li><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font face="Arial">Hyo Jin Khang</font></font></font></span></span></li> <li><span><span style="font-family: 'Times New Roman'; font-size: 12pt" lang="EN-US"><font size="5"><font size="3"><font face="Arial">[http://biocountryjongbhak.net com Jong Bhak]: The international portal for biological information for the countriesJong is a [[bioinformatist]] living in Asia now.</font></font></font></span></span></li> <li><font size="3">Sohyun Hwang</font></li> <li><font size="3">[http://biocoursebio.org Biocourse.orgcc/wykim Woo-Yeon Kim]</font></li> <li><font size="3">Jin Ok Yang</font>&nbsp;</li></ul><p><strong><font size="3">[[Variomics and SNP References]]</font></strong><br />&nbsp;</p><p><font color="#000080" size="2"><span style="color: navy; font-size: 10pt">&nbsp;&nbsp;&nbsp; 1. Prichard et al, 2000, Inference of Population Structure Using Multilocus Genotype Data, Genetics, 155, 945-959.<br /></span></font><font color="#000080" size="2"><span style="color: navy; font-size: 10pt">&nbsp;&nbsp;&nbsp; 2. Bowcock et al, 1994, High resolution of human evolutionary trees with polymorphic microsatellites, Nature, 368, 31, 455-457.<br /></span></font><font color="#000080" size="2"><span style="color: navy; font-size: 10pt">&nbsp;&nbsp;&nbsp; 3. Shriver et al, 2004, The genome distribution of population substructure in four populations using 8,524 autosomal SNPs.<br /></span></font><font color="#000080" size="2"><span style="color: navy; font-size: 10pt">&nbsp;&nbsp;&nbsp; 4. Shriver et al, 2005, Large-scale SNP analysis reveals clustered and continuous patterns o f human genetic variation.<br /></span></font><font color="#000080" size="2"><span style="color: navy; font-size: 10pt">&nbsp;&nbsp;&nbsp; 5. Adeyemo et al, 2005, Genetic structure in four West African population groups.<br /></span></font><font color="#000080" size="2"><span style="color: navy; font-size: 10pt">&nbsp;&nbsp;&nbsp; 6. Chakraborty and Jin, 1993, A unified approach to study hypervariable polymorphisms: Statistical considerations of determining relatedness and population distances.<br /></span></font></p><p><li><a href="http://biocoursenar.oupjournals.org ]/cgi/content/full/31/1/124">The SNP Consortium website: Biological training past, present, and learning materials portalfuture</a> - From <em>Nucleic Acids Research</em> <strong>31</strong>(1), 124-27 (2003).</li><li><a href="http://www.biotechniques.com/snps/articles/060201.pdf">Introduction to SNPs: Discovery of Markers for Disease</a> - From <em>BioTechniques</em>, June 2002 (pdf).</li><li><a href="http://www.the-scientist.com/yr2002/apr/profile_020415.html">Prospecting for Gold in Genome Gulch</a> - From <em>The Scientist</em>, April 2002<strong>.</strong></li><li><a href="http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v409/n6822/full/409821a0_fs.html">Single nucleotide polymorphisms: From the evolutionary past...</a> - From <em>Nature</em>, February 2001.</li><li><a href="http://www.nature.com/cgi-taf/DynaPage.taf?file=/nature/journal/v409/n6822/full/409822a0_fs.html">Single nucleotide polymorphisms: . . .to a future of genetic medicine</a> - From <em>Nature</em>, February 2001. <br /><p>&nbsp;</p></li></p>
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